Monitoring Additive Manufacturing Machine Health

Additive manufacturing (AM) allows the production of parts and goods with many benefits over more conventional manufacturing methods. AM permits more geometrically complex designs, custom and low-volume production runs, and the flexibility to produce a wide variety of parts on a single machine with reduced pre-production cost and time requirements. However, it can be difficult to determine the condition, or health, of an AM machine since complex designs can increase the variability of part quality. With fewer parts produced, destructive testing is less desirable and statistical methods of tracking part quality may be less informative. Combined with the relatively more complex nature of AM machines, qualifying AM machines and monitoring their health to perform maintenance or repairs is a challenging task. We first present a case study that demonstrates the difficulty of monitoring the qualification of an AM machine. We then discuss some unique challenges AM presents when calibrating and taking measurements of laser power, and we demonstrate the relative insufficiency of this method in tracking the qualification status of an AM machine and the quality of the parts produced. Next, we present a framework that reverses the directionality of monitoring AM machine health. Rather than monitoring machine subsystems and intermediate metrics reflective of part quality, we instead directly monitor part quality through a combination of witness builds and witness parts that provide observational data to define the health status of a machine. Witness builds provide more accurate data separated from the noisy influence of parts and parameter settings, while witness artifacts provide more timely data but with less accuracy. Finally, machine health is modeled as a partially observed Markov decision process using the witness parts framework to maximize the long-term expected value per build. We show the superiority of this model by comparison to two less complex models, one that uses no use no witness parts and another that uses only witness builds. A case study shows the benefits of implementing the model, and a sensitivity analysis is performed to show relevant insights and considerations

Preparing for operation GRITROCK : military medical ethics challenges encountered in the planning stages of the UK Ebola response mission

In early September 2014, Médecins sans Frontières (MSF) took the unusual step of calling on governments to deploy military, as well as civilian, assets to help combat the Ebola Virus Disease (EVD) epidemic raging in West Africa (MSF, 2014). The UK government announced a package of aid in response to the outbreak, including the deployment of military experts, targeted primarily on Sierra Leone. (Gov.UK 2014) The scale of the outbreak and the responses to it attracted comment from many quarters and raised ethical issues. We were interested in the ethical challenges that would confront the troops on the ground in Sierra Leone, particularly those who were healthcare professionals. We successfully secured UK funding council research funds to explore these challenges. During the preparatory stages of this project, however, it became clear that ethical decisions had also been made during the planning stages of the deployment in anticipation of issue that may be faced on the deployment. These planning issues are of interest in their own right, even though they fell outside the aims of our project, and we explore of some these in this chapter

Flavonoids as modulators of memory and learning: molecular interactions resulting in behavioural effects

There is considerable interest in the potential of a group of dietary-derived phytochemicals known as flavonoids in modulating neuronal function and thereby influencing memory, learning and cognitive function. The present review begins by detailing the molecular events that underlie the acquisition and consolidation of new memories in the brain in order to provide a critical background to understanding the impact of flavonoid-rich diets or pure flavonoids on memory. Data suggests that despite limited brain bioavailability, dietary supplementation with flavonoid-rich foods, such as blueberry, green tea and Ginkgo biloba lead to significant reversals of age-related deficits on spatial memory and learning. Furthermore, animal and cellular studies suggest that the mechanisms underpinning their ability to induce improvements in memory are linked to the potential of absorbed flavonoids and their metabolites to interact with and modulate critical signalling pathways, transcription factors and gene and/or protein expression which control memory and learning processes in the hippocampus; the brain structure where spatial learning occurs. Overall, current evidence suggests that human translation of these animal investigations are warranted, as are further studies, to better understand the precise cause-and-effect relationship between flavonoid intake and cognitive outputs

On the alleged simplicity of impure proof

Roughly, a proof of a theorem, is “pure” if it draws only on what is “close” or “intrinsic” to that theorem. Mathematicians employ a variety of terms to identify pure proofs, saying that a pure proof is one that avoids what is “extrinsic,” “extraneous,” “distant,” “remote,” “alien,” or “foreign” to the problem or theorem under investigation. In the background of these attributions is the view that there is a distance measure (or a variety of such measures) between mathematical statements and proofs. Mathematicians have paid little attention to specifying such distance measures precisely because in practice certain methods of proof have seemed self- evidently impure by design: think for instance of analytic geometry and analytic number theory. By contrast, mathematicians have paid considerable attention to whether such impurities are a good thing or to be avoided, and some have claimed that they are valuable because generally impure proofs are simpler than pure proofs. This article is an investigation of this claim, formulated more precisely by proof- theoretic means. After assembling evidence from proof theory that may be thought to support this claim, we will argue that on the contrary this evidence does not support the claim

Children's Book Awards in Australia: Their Effects on the Literary Marketplace

This study explores the outcomes resulting from the formal recognition of selected children's literature in Australia for six stakeholder cohorts. For the purposes of this research, the recognition was in the form of a children's or young adult literary award. The process leading to an award is documented in policies, reports and handbooks and some publicity is evident in the media, journals, online sources and popular literary magazines. However, the outcomes of this personal, corporate, organizational, social, cultural and economic activity have not been examined to date and this research project addresses the question of exactly what happens to the selected stakeholders after the winning announcement is made. Out of the general focus question there arose subsidiary questions relating to the strength of the impacts, the longevity of the impacts, the current knowledge of a range of awards and responses in terms of income or impressions of award related promotional activity. Selecting meaningful and relevant populations to survey and to clarify relevance and vocabulary in questioning involved a pilot study and resulted in a survey structure of six cohorts to represent the affected field. The survey method involved mailed questionnaires. In the construction of the questionnaires it was apparent that cohort-specific questionnaires would be necessary for there were very few avenues of questioning which were common across all cohorts. As these questionnaires were developed the research design evolved into six mini-projects which had some elements in common but also unique features and perspectives. The evolution of book awards over time is explored in this work. Recognition and dedicated publishing of Australian children's literature slowly developed out of children's literature published in Great Britain, the mother country. This thesis briefly follows this growth and development of literary works for children and the awarding of prizes for exceptional quality, revealing the shifts in perception of the nature of the child reader and society's perception of what constitutes a quality child's book in Australia. Book awards for children's literature did not arise spontaneously but were an expression of interest, respect and maturity in the development of Australian literature

Developing core principles for sharing Information about potential intervention benefits and harms in patient information leaflets using a modified Delphi Survey

Patients need to be informed about potential risks of taking part in clinical trials. A problem is that there are no standards telling researchers or ethics committees how these risks need to be communicated. Our background research suggests that the way harms are communicated can actually increase the risks of the harms occurring. Over half of our sample of 250,000 patients who took placebo pills (like sugar pills) in clinical trials reported some negative side effect (like pain or nausea but also more serious things). The aim of this study is to understand what information about trial harms and benefits stakeholders consider to be important for ‘principled participant information leaflets’ or ‘PrinciPILs’ to contain. The stakeholders will include patients, ethics committee members, industry representatives, medico-legal experts, psychologists, and trial managers

Developing principles for sharing information about potential trial intervention benefits and harms with patients: report of a modified Delphi survey

Background The way information about potential harms of trial intervention is shared within participant information leaflets (PILs) varies widely and can cause subjective ‘nocebo’ harms. This study aimed to develop principles to improve the composition of information about potential trial intervention benefits and harms within PILs so that variability and avoidable harms are reduced. Methods We conducted a two-round modified online Delphi survey, followed by a consensus meeting. For the first round of the survey, 27 statements were developed based on previous research and relevant guidance from the UK, the USA and the World Health Organization. Participants included members from each of the following stakeholder groups: patient and public representatives, research ethics committee members, industry representatives, medico-legal experts, psychologists and trial managers. Each participant was asked to rate their degree of agreement or disagreement with each statement on a 9-point Likert scale. In the second round, participants were invited to reappraise their ratings after reviewing the results of the first round. Finally, two members from each stakeholder group participated in a meeting to confirm those statements for which there was agreement. Results Two hundred and fifty participants completed round 1, and 201 participants completed round 2. In round 1, consensus was reached for 16 statements. In round 2, consensus was reached for an additional three statements. The consensus meeting confirmed the survey results and consolidated the statements. This process resulted in seven principles: (1) all potential harms of a given intervention should be listed, (2) all potential harms should be separated into serious and less serious, (3) it must be made explicit that not all potential harms are known, (4) all potential benefits should be listed, (5) all potential benefits and harms need to be compared with what would happen if the participant did not take part in the trial, (6) suitable visual representations should be added where appropriate and (7) information regarding potential benefits and harms should not be presented apart by one or more pages. Conclusions Our modified Delphi process successfully generated seven principles that can and should be used to guide how information is conveyed to patients in information leaflets regarding potential trial benefits and harms

MFA15 (MFA 2015)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum, May 1 - August 2, 2015 . Introduction / Heather Corcoran and Patricia Olynyk -- Diana Casanova / Emily J. Hanson -- Andrea M. Coates : in the operating theater / Stephanie Dering -- Margaux Crump -- Brandon Daniels -- Addoley Dzegede : do you prefer answers or truth? / Aaron Coleman -- Vita Eruhimovitz -- Carling Hale -- Amanda Helman -- Mike Helms / Ming Ying Hong -- Ming Ying Hong / Emily J. Hanson -- Sea A Joung / Ervin Malakaj -- Stephanie Kang / Jeremy Shipley -- Dayna Jean Kriz / Andrew Johnson -- Thomas Moore : you should move to the city / Nathaniel Rosenthalis -- Jacob Muldowney -- Laurel Panella / Garrett Clough -- Caitlin Penny -- On the bridge, between Juarez and El Paso / Eric Lyle Schultz -- Jeremy Shipley -- Emmeline Solomon -- Kellie Spano / Margaux Crump -- Michael Aaron Williams -- Austin R. Wolf : monumental labor / Adam Turl.https://openscholarship.wustl.edu/books/1015/thumbnail.jp

Comparing phoneme frequency, age of acquisition, and loss in aphasia:Implications for phonological universals

Phonological complexity may be central to the nature of human language. It may shape the distribution of phonemes and phoneme sequences within languages, but also determine age of acquisition and susceptibility to loss in aphasia. We evaluated this claim using frequency statistics derived from a corpus of phonologically transcribed Italian words (phonitalia, available at phonitalia,org), rankings of phoneme age of acquisition (AoA) and rate of phoneme errors in patients with apraxia of speech (AoS) as an indication of articulatory complexity. These measures were related to cross-linguistically derived markedness rankings. We found strong correspondences. AoA, however, was predicted by both apraxic errors and frequency, suggesting independent contributions of these variables. Our results support the reality of universal principles of complexity. In addition they suggest that these complexity principles have articulatory underpinnings since they modulate the production of patients with AoS, but not the production of patients with more central phonological difficulties

Colitis and Colon Cancer in WASP-Deficient Mice Require Helicobacter Species

Background: Wiskott–Aldrich syndrome protein–deficient patients and mice are immunodeficient and can develop inflammatory bowel disease. The intestinal microbiome is critical to the development of colitis in most animal models, in which Helicobacter spp. have been implicated in disease pathogenesis. We sought to determine the role of Helicobacter spp. in colitis development in Wiskott–Aldrich syndrome protein–deficient (WKO) mice. Methods: Feces from WKO mice raised under specific pathogen-free conditions were evaluated for the presence of Helicobacter spp., after which a subset of mice were rederived in Helicobacter spp.–free conditions. Helicobacter spp.–free WKO animals were subsequently infected with Helicobacter bilis. Results: Helicobacter spp. were detected in feces from WKO mice. After rederivation in Helicobacter spp.–free conditions, WKO mice did not develop spontaneous colitis but were susceptible to radiation-induced colitis. Moreover, a T-cell transfer model of colitis dependent on Wiskott–Aldrich syndrome protein–deficient innate immune cells also required Helicobacter spp. colonization. Helicobacter bilis infection of rederived WKO mice led to typhlitis and colitis. Most notably, several H. bilis–infected animals developed dysplasia with 10% demonstrating colon carcinoma, which was not observed in uninfected controls. Conclusions: Spontaneous and T-cell transfer, but not radiation-induced, colitis in WKO mice is dependent on the presence of Helicobacter spp. Furthermore, H. bilis infection is sufficient to induce typhlocolitis and colon cancer in Helicobacter spp.–free WKO mice. This animal model of a human immunodeficiency with chronic colitis and increased risk of colon cancer parallels what is seen in human colitis and implicates specific microbial constituents in promoting immune dysregulation in the intestinal mucosa.National Institutes of Health (U.S.) (R01OD011141)National Institutes of Health (U.S.) (R01CA067529)National Institutes of Health (U.S.) (P01CA026731)National Institutes of Health (U.S.) (P30ES02109